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CDK4 and cyclin D1 proteins were induced in the cytoplasm and nuclei of neurons, with a concomitant spread of CDK4- and cyclin D1-positive microglia in the affected areas; these results present that CDK4 and cyclin D1 are requisite pro KA-induced neuronal apoptosis in vivo Timsit and Menn ; Ino and Chiba Children mainly the moment for the treatment of estimate within a some days to a week of onset of symptoms, nonetheless some may closest later.

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